TY - JOUR T1 - Neural activity modulations and motor recovery following brain-exoskeleton interface mediated stroke rehabilitation JF - NeuroImage: Clinical Y1 - 2020 A1 - Nikunj A. Bhagat A1 - Nuray Yozbatiran A1 - Jennifer L. Sullivan A1 - Ruta Paranjape A1 - Colin Losey A1 - Zachary Hernandez A1 - Zafer Keser A1 - Robert Grossman A1 - Gerard E. Francisco A1 - Marcia K. O'Malley A1 - Jose L. Contreras-Vidal KW - Brain-machine interface KW - Clinical trial KW - Exoskeletons KW - Movement related cortical potentials KW - stroke rehabilitation AB -

Brain-machine interfaces (BMI) based on scalp EEG have the potential to promote cortical plasticity following stroke, which has been shown to improve motor recovery outcomes. However, the efficacy of BMI enabled robotic training for upper-limb recovery is seldom quantified using clinical, EEG-based, and kinematics-based metrics. Further, a movement related neural correlate that can predict the extent of motor recovery still remains elusive, which impedes the clinical translation of BMI-based stroke rehabilitation. To address above knowledge gaps, 10 chronic stroke individuals with stable baseline clinical scores were recruited to participate in 12 therapy sessions involving a BMI enabled powered exoskeleton for elbow training. On average, 132 ± 22 repetitions were performed per participant, per session. BMI accuracy across all sessions and subjects was 79 ± 18% with a false positives rate of 23 ± 20%. Post-training clinical assessments found that FMA for upper extremity and ARAT scores significantly improved over baseline by 3.92 ± 3.73 and 5.35 ± 4.62 points, respectively. Also, 80% participants (7 with moderate-mild impairment, 1 with severe impairment) achieved minimal clinically important difference (MCID: FMA-UE >5.2 or ARAT >5.7) during the course of the study. Kinematic measures indicate that, on average, participants’ movements became faster and smoother. Moreover, modulations in movement related cortical potentials, an EEG-based neural correlate measured contralateral to the impaired arm, were significantly correlated with ARAT scores (ρ = 0.72, p < 0.05) and marginally correlated with FMA-UE (ρ = 0.63, p = 0.051). This suggests higher activation of ipsi-lesional hemisphere post-intervention or inhibition of competing contra-lesional hemisphere, which may be evidence of neuroplasticity and cortical reorganization following BMI mediated rehabilitation therapy.

VL - 28 UR - http://www.sciencedirect.com/science/article/pii/S2213158220303399 ER - TY - Generic T1 - Detecting movement intent from scalp EEG in a novel upper limb robotic rehabilitation system for stroke T2 - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Y1 - 2014 A1 - N. A. Bhagat A1 - J. French A1 - A. Venkatakrishnan A1 - N. Yozbatiran A1 - G. E. Francisco A1 - M. K. O'Malley A1 - J. L. Contreras-Vidal KW - Accuracy KW - Adult KW - bioelectric potentials KW - brain-computer interfaces KW - closed loop systems KW - closed-loop brain-machine interfaces KW - Computer-Assisted KW - diseases KW - electroencephalography KW - Electromyography KW - Exoskeletons KW - hemiparesis KW - Humans KW - Male KW - medical robotics KW - medical signal detection KW - medical signal processing KW - Middle Aged KW - Movement KW - movement intent detection KW - neurophysiology KW - Paresis KW - Patient rehabilitation KW - Robotics KW - Robots KW - scalp electroencephalography KW - Signal Processing KW - stroke KW - stroke rehabilitation KW - Support Vector Machine KW - Support vector machines KW - training KW - Upper Extremity KW - upper extremity dysfunction KW - upper limb robotic rehabilitation system KW - Young Adult JF - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ER - TY - Generic T1 - System characterization of RiceWrist-S: A forearm-wrist exoskeleton for upper extremity rehabilitation T2 - Rehabilitation Robotics (ICORR), 2013 IEEE International Conference on Y1 - 2013 A1 - Pehlivan, Ali Utku A1 - Rose, Chad G. A1 - O'Malley, Marcia K. KW - Actuators KW - closed loop position performance KW - closed loop systems KW - distal joints KW - Exoskeletons KW - forearm rehabilitation KW - forearm-wrist exoskeleton KW - Friction KW - haptic interface design KW - Joints KW - medical robotics KW - neurological lesions KW - neurophysiology KW - Patient rehabilitation KW - position control KW - prosthetics KW - RiceWrist-S KW - robotic rehabilitation KW - Robots KW - serial mechanisms KW - spatial resolution KW - spinal cord injury KW - spinal cord injury rehabilitation KW - stroke KW - stroke rehabilitation KW - system characterization KW - Torque KW - torque output KW - upper extremity rehabilitation KW - Wrist KW - wrist rehabilitation JF - Rehabilitation Robotics (ICORR), 2013 IEEE International Conference on ER -